Best Mattress Cover for Allergies: Top Waterproof and Hypoallergenic Picks

Last Updated on December 13, 2025 by Cassie Moorhead

Waking up with itchy eyes, sneezing fits, or a stuffy nose can make mornings feel like a struggle. If allergies have ever kept you from a good night’s sleep, you know how frustrating it is.

Dust mites, pet dander, and other allergens hide deep in mattresses, making symptoms worse without us realizing it. But the right mattress cover can change everything. It acts like a shield, blocking those tiny irritants and giving you a cleaner, healthier place to rest.

Imagine waking up refreshed, breathing easy, and feeling ready for the day. In this article, we’ll explore some of the best mattress covers for allergies. These picks can help you find relief and improve your sleep quality. Keep reading to discover which one fits your needs perfectly.

Hospitology Products Mattress Encasement

The HOSPITOLOGY PRODUCTS Mattress Encasement is ideal for individuals seeking a reliable solution to protect their mattress from bed bugs, dust mites, and allergens. Perfect for allergy sufferers, families with young children, or anyone wanting to extend the life of their mattress while ensuring a hygienic and comfortable sleep environment. This encasement is especially beneficial for those who want a waterproof and stretchable cover that fits standard queen-sized mattresses with a 12-inch depth.

Pros:

• Bed Bug and Dust Mite Proof: Effectively blocks pests and allergens for a healthier sleep.
• Hypoallergenic Material: Reduces allergic reactions and promotes better respiratory health.
• Waterproof Protection: Shields mattress from spills and stains, increasing durability.
• Stretchable Fabric: Ensures a snug fit on mattresses up to 12 inches deep.
• Zippered Design: Provides easy installation and complete mattress coverage.
• Standard Queen Size: Fits mattresses measuring 60″ W x 80″ L perfectly.

Cons:

• May produce slight noise due to waterproof material when moving.
• White color might show dirt or stains more easily over time.

The HOSPITOLOGY PRODUCTS Mattress Encasement combines practical features with user-friendly design to enhance your sleeping experience. Its zipper closure fully encases the mattress, preventing bed bugs and dust mites from penetrating, which is essential for maintaining a clean and allergen-free sleep environment. The stretchable fabric accommodates a mattress depth of up to 12 inches, ensuring a secure and wrinkle-free fit that stays in place night after night.

Additionally, the waterproof layer safeguards your mattress from accidental spills and stains, preserving its condition and extending its lifespan. This feature is particularly beneficial for households with children or pets. The hypoallergenic properties of the encasement further contribute to improved health by minimizing exposure to common allergens, helping users enjoy a more restful and comfortable sleep. Overall, this mattress encasement provides comprehensive protection and peace of mind for anyone looking to maintain a pristine sleeping surface.

To buy this product, click here.

Allerease Waterproof Mattress Protector

The AllerEase Waterproof Mattress Protector is perfect for individuals seeking to protect their mattress from allergens, spills, and stains while ensuring a comfortable sleeping environment. Ideal for allergy sufferers, families with children, or anyone looking to extend the life of their queen mattress, this mattress cover provides both durability and protection.

Pros:

• Waterproof barrier prevents spills and stains from damaging the mattress
• Maximum allergy protection helps reduce exposure to dust mites and allergens
• Fits a queen mattress with dimensions of 59.5” x 79.5” and up to 13” deep
• Lightweight at 2.0 pounds, ensuring it does not add bulk or heat
• Manufactured by the trusted American Textile Company under the Aller-Ease brand
• Easy to clean and maintain, improving bedroom hygiene

Cons:

• May have a slight crinkling sound when moving on the mattress
• Limited to queen size, not suitable for other mattress sizes

The AllerEase Waterproof Mattress Protector features a breathable yet waterproof fabric that safeguards your mattress from liquids without sacrificing comfort. Its allergen-blocking technology is designed to trap dust mites, pet dander, and other common irritants, making it an excellent choice for allergy sufferers. The protector’s white color blends seamlessly with most bedding styles, maintaining a clean and fresh look in your bedroom.

Measuring 59.5 inches wide, 79.5 inches long, and 13 inches high, this mattress cover fits snugly over standard queen mattresses while remaining lightweight at only 2.0 pounds. This ensures it does not interfere with your sleeping experience. Backed by the American Textile Company, the AllerEase protector combines quality manufacturing with practical design to enhance mattress longevity and provide peace of mind against spills and allergens.

To buy this product, click here.

Allerease Ultimate Allergy Protection And Comfort Zippered Mattress Protector

The AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector, Queen is ideal for individuals who suffer from allergies or asthma and want to maintain a clean and healthy sleeping environment. This mattress protector is perfect for those seeking to prevent allergens such as dust mites, pet dander, and pollen from affecting their sleep quality. It is also suitable for anyone looking to protect their mattress from spills, stains, and wear while enjoying added comfort.

Pros:

• Effective allergy barrier: prevents dust mites and allergens from penetrating the mattress.
• Zippered design: ensures full coverage and secure fit around the mattress.
• Comfortable material: provides a soft and breathable sleeping surface.
• Durable construction: made by reputable brand Aller-Ease and manufacturer American Textile.
• Fits queen size mattresses: with dimensions suitable for standard queen beds.
• Easy to clean: machine washable for convenient maintenance.

Cons:

• May add slight warmth due to protective layers.
• Zipper could potentially wear out with frequent use.
• Limited color options, available only in white.

The AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector offers comprehensive protection by completely encasing the mattress with a zipper closure, blocking allergens effectively. Its breathable fabric ensures that users do not compromise on comfort while benefiting from a hypoallergenic sleep surface. This protector’s design also helps prolong the life of the mattress by shielding it from spills, stains, and dust, making it a practical investment for long-term mattress care.

With dimensions tailored to fit queen-sized beds and a lightweight profile of just 2.0 pounds, the mattress protector is easy to handle and install. The trusted brand and manufacturer behind this product enhance its reliability and quality assurance. Overall, this mattress protector combines health benefits with comfort and durability, making it a smart choice for anyone wanting a restful and allergen-free night’s sleep.

To buy this product, click here.

Saferest Waterproof Queen Size Mattress Protector

The SafeRest Waterproof Queen Size Mattress Protector is ideal for individuals seeking to protect their mattress from spills, stains, and allergens while maintaining comfort. Perfect for families with children, pet owners, or anyone who wants to extend the life of their mattress, this mattress cover offers reliable protection combined with ease of use.

Pros:

• Waterproof design prevents liquids from penetrating the mattress.
• Stretchable fitted pockets ensure a snug fit on queen size mattresses.
• Made from machine washable cotton for easy cleaning and maintenance.
• Lightweight yet durable with a weight of just 1.92 pounds.
• Offers protection without compromising mattress comfort or breathability.

Cons:

• May not fit mattresses thicker than 11.1 inches perfectly.
• Only available in white, limiting color options.

The SafeRest Waterproof Queen Size Mattress Protector features a waterproof barrier that shields your mattress from accidental spills, sweat, and dust mites. Its fitted design with stretchable pockets allows it to securely wrap around mattresses up to 11.1 inches deep, preventing any slipping or bunching during sleep. Additionally, the cotton fabric used is soft and breathable, promoting a comfortable sleeping environment without heat retention.

Beyond protection, this mattress cover is easy to care for since it is machine washable and retains its waterproof qualities even after multiple washes. Its lightweight construction means it adds minimal bulk while providing a hygienic and allergen-free surface to sleep on. Overall, this mattress protector combines practical features with user-friendly benefits, making it a smart choice for maintaining mattress cleanliness and longevity.

To buy this product, click here.

Utopia Bedding Waterproof Mattress Protector Queen Size

The Utopia Bedding Waterproof Mattress Protector Queen Size is ideal for anyone looking to extend the life of their mattress while ensuring a clean and allergen-free sleeping environment. This product is perfect for families with kids, pet owners, allergy sufferers, and those living in areas prone to dust mites and bed bugs. If you want a hassle-free, secure, and comfortable mattress cover, this six-sided zippered encasement is the right choice.

Pros:

• Waterproof protection safeguards mattress from spills and stains
• Zippered mattress encasement provides a secure and snug fit
• Bed bug and dust mite proof helps reduce allergens and pests
• Absorbent six-sided cover offers full mattress coverage
• Fits queen size mattress with dimensions up to 15 inches deep
• Made by trusted brand Utopia Bedding ensuring quality and durability

Cons:

• May have a slight crinkling noise initially due to waterproof material
• Zipper can be challenging to close on thicker mattresses

The Utopia Bedding Waterproof Mattress Protector is designed with a zippered enclosure that fully encases the mattress, providing 360-degree protection. This prevents liquids, dust mites, and bed bugs from penetrating the mattress, enhancing hygiene and comfort. The waterproof layer ensures that accidental spills or sweat do not stain or damage the mattress, prolonging its lifespan. Its absorbent nature also helps in maintaining a dry sleeping surface, which is essential for a restful night’s sleep.

Constructed to fit mattresses up to 15 inches in height, this encasement is versatile and fits most queen-sized beds perfectly. The white color adds a clean and crisp look to your bedding ensemble. Furthermore, the product is easy to maintain and can be machine washed, making it convenient for everyday use. With Utopia Bedding’s focus on quality, users can expect a durable and reliable mattress protector that balances protection with comfort.

To buy this product, click here.

Frequently Asked Questions

What Mattress Cover Is Best For Allergy Protection?

The HOSPITOLOGY PRODUCTS Mattress Encasement offers excellent allergy protection. It blocks dust mites, bed bugs, and allergens effectively. Its waterproof and hypoallergenic features add extra defense for sensitive sleepers. This cover is ideal for allergy sufferers seeking comprehensive protection and comfort.

Are Waterproof Mattress Covers Good For Allergies?

Yes, waterproof mattress covers prevent allergens from penetrating the mattress. They block dust mites, mold, and spills, reducing allergic reactions. Products like AllerEase Waterproof Mattress Protector combine allergy protection with waterproofing. This makes them a practical choice for allergy sufferers.

How Does A Zippered Mattress Protector Help Allergies?

Zippered mattress protectors create a complete seal around the mattress. This stops dust mites and allergens from entering or escaping. AllerEase Ultimate Allergy Protection uses a zippered design for full defense. It’s especially useful for those with severe allergies or asthma.

Can Mattress Covers Prevent Bed Bugs And Dust Mites?

Yes, mattress covers like Utopia Bedding and SafeRest are designed to be bed bug and dust mite proof. They form a barrier that prevents these pests from infesting the mattress. Regular use helps maintain a cleaner, allergen-free sleeping environment.

Are Stretchable Mattress Covers Comfortable For Allergy Sufferers?

Stretchable mattress covers, such as the HOSPITOLOGY PRODUCTS encasement, offer a snug, comfortable fit. They adapt to mattress depth and movement without bunching. This comfort enhances sleep quality while providing allergy protection, making them a preferred choice for sensitive sleepers.

Conclusion

Choosing the right mattress cover can greatly reduce allergy problems and improve sleep quality. Products like HOSPITOLOGY, AllerEase, SafeRest, and Utopia Bedding offer reliable protection against dust mites, bed bugs, and allergens. Many of these covers are waterproof and easy to clean, helping keep your mattress fresh and safe.

A good mattress protector acts as a barrier, preventing allergens from settling into your bedding. This means fewer allergy symptoms and a healthier sleep environment. Remember to pick a cover that fits your mattress size and depth well. Regular washing will also keep allergens away.

With the right mattress cover, you can enjoy cleaner air and better rest every night. Small changes like this make a big difference for allergy sufferers. Your comfort and health are worth it.