Best Allergy Cover for Mattress: Top Waterproof & Hypoallergenic Picks

Last Updated on December 13, 2025 by Cassie Moorhead

Waking up with itchy eyes or a stuffy nose can ruin your whole day. It’s frustrating when allergies keep you from getting a good night’s sleep.

Dust mites, bed bugs, and allergens hide in mattresses, making symptoms worse. But finding the right allergy cover for your mattress can change everything. A quality mattress protector creates a barrier, keeping irritants away while you rest peacefully. It’s more than just protection—it’s about comfort and peace of mind every night.

In this article, we’ll explore some of the best allergy covers available. These products can make your daily life easier and your sleep healthier. Keep reading to discover which mattress protectors offer the best defense and comfort for a better night’s rest.

Hospitology Products Mattress Encasement

The HOSPITOLOGY PRODUCTS Mattress Encasement is ideal for individuals seeking a comprehensive solution to protect their mattress from bed bugs, dust mites, and allergens. This product is perfect for allergy sufferers, families with children, or anyone wanting to maintain a clean and hygienic sleeping environment. Its waterproof and stretchable design also makes it suitable for those who want to safeguard their mattress against spills and stains without compromising comfort.

Pros:

• Bed bug and dust mite proof with a secure zippered enclosure
• Hypoallergenic material ideal for allergy sufferers
• Waterproof and stretchable for added mattress protection and comfort
• Fits standard mattresses up to 12 inches in depth
• Durable and lightweight with easy-to-clean fabric

Cons:

• Only available in Queen size (60″ W x 80″ L), limiting options for other mattress sizes
• The white color may show stains or dirt more easily over time

The HOSPITOLOGY PRODUCTS Mattress Encasement features a high-quality zippered design that fully encases the mattress, ensuring that no bed bugs or dust mites can penetrate. This not only improves sleep quality by reducing exposure to allergens but also extends the lifespan of your mattress by preventing damage from pests and spills. The waterproof layer protects against any liquid accidents, making it especially beneficial for households with children or pets.

Additionally, the stretchable fabric allows the encasement to fit snugly on mattresses up to 12 inches deep without restricting movement or comfort. Its hypoallergenic properties provide peace of mind to those with sensitive skin or respiratory issues, while the lightweight design makes installation and maintenance hassle-free. Overall, this mattress encasement offers a reliable and comfortable sleep defense system to enhance your bedroom hygiene and wellness.

To buy this product, click here.

Allerease Waterproof Mattress Protector

The AllerEase Waterproof Mattress Protector is ideal for individuals who suffer from allergies or want to protect their mattress from spills and stains. If you are someone who values a clean, hygienic sleeping environment or has pets and children at home, this Maximum Allergy Mattress Protector is an excellent choice. It is especially suitable for those with a Queen-sized mattress looking for reliable mattress protection.

Pros:

• Effective waterproof barrier to protect against spills and stains
• Hypoallergenic material reduces exposure to allergens and dust mites
• Fits mattresses up to 13 inches deep, including queen size dimensions (59.5″ x 79.5″)
• Lightweight design at 2.0 pounds for easy handling and washing
• Durable construction by reputable brand Aller-Ease and manufacturer American Textile Company
• Breathable white fabric maintains mattress comfort and airflow

Cons:

• May produce slight noise when moving due to waterproof layer
• Only available in white, limiting color options

The AllerEase Waterproof Mattress Protector offers robust protection with a waterproof layer that prevents any liquid from seeping into your mattress, which is essential for maintaining mattress longevity and cleanliness. Its hypoallergenic properties are designed to minimize contact with dust mites and allergens, which can significantly improve sleep quality for allergy sufferers. The protector’s breathable fabric ensures you remain comfortable throughout the night without overheating.

Designed to fit queen-sized mattresses up to 13 inches deep, this mattress protector combines functionality with convenience. Its lightweight nature makes it easy to remove and wash regularly, helping maintain a fresh sleeping environment. The trusted manufacturing by the American Textile Company and quality assurance from Aller-Ease provide peace of mind that you are investing in a reliable and durable product.

To buy this product, click here.

Allerease Ultimate Allergy Protection And Comfort Zippered Mattress Protector

The AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector, Queen is perfect for individuals who suffer from allergies or asthma, as well as those looking to extend the life of their mattress. If you want to create a cleaner, healthier sleeping environment free from dust mites, allergens, and bed bugs, this mattress protector is an ideal choice. It is especially suitable for allergy sufferers, families with children, and anyone seeking added comfort and protection for their mattress.

Pros:

• Provides ultimate allergy protection by blocking dust mites, allergens, and bed bugs
• Features a zippered enclosure for full mattress coverage and secure fit
• Made by trusted brand Aller-Ease, known for quality allergy products
• White color easily blends with most bedding styles
• Comfortable and breathable material enhances sleep quality
• Dimensions are suitable for a standard queen size mattress

Cons:

• May feel slightly bulky to some users due to the zipper design
• Requires regular washing to maintain effectiveness and cleanliness
• Price might be higher compared to basic mattress protectors without allergy features

The AllerEase Ultimate Allergy Protection and Comfort Zippered Mattress Protector is designed with advanced technology to provide a barrier against common allergens such as dust mites and bed bugs. The zippered enclosure ensures that your entire mattress is fully covered, preventing allergens from penetrating the mattress surface. This feature is particularly beneficial for allergy sufferers who need to minimize exposure to triggers that can disrupt sleep and affect health. The breathable material also promotes airflow, helping to maintain a comfortable sleeping temperature.

Additionally, this mattress protector is built for durability and ease of use. Its snug fit around a queen size mattress prevents shifting during the night, ensuring continuous protection. The white color complements any bedroom décor while the high-quality fabric adds a layer of comfort on top of your mattress. Overall, it offers a practical and health-conscious solution for anyone looking to improve their sleep environment and protect their mattress investment.

To buy this product, click here.

Saferest Waterproof Queen Size Mattress Protector

The SafeRest Waterproof Queen Size Mattress Protector is an excellent choice for individuals seeking to extend the life of their mattress and ensure a hygienic sleeping environment. Ideal for families with children, pet owners, or anyone prone to spills and stains, this mattress cover provides reliable protection while maintaining comfort. Those who prioritize easy maintenance and durable bedding accessories will find this product particularly beneficial.

Pros:

• Made with waterproof materials to prevent stains and spills from damaging the mattress.
• Features stretchable fitted pockets that ensure a snug fit on queen size mattresses up to 11.1 inches deep.
• Constructed from machine washable cotton for effortless cleaning and long-lasting use.
• Lightweight design at just under 2 pounds, making it easy to handle and install.
• Neutral white color that blends seamlessly with most bedding styles.

Cons:

• May have a slight initial odor typical of waterproof materials, requiring airing out.
• Not suitable for mattresses thicker than 11.1 inches.

This SafeRest mattress protector stands out due to its combination of comfort and protection. The cotton fabric ensures breathability, helping to maintain a comfortable sleeping temperature throughout the night. Meanwhile, the waterproof barrier beneath the surface safeguards the mattress from accidental spills, sweat, and allergens, making it an excellent choice for allergy sufferers and those wanting to preserve mattress hygiene.

Additionally, the stretchable fitted pockets provide a secure and wrinkle-free fit, preventing the cover from slipping or bunching during sleep. This feature contributes to a smooth, comfortable surface that enhances overall sleep quality. The ease of machine washing means upkeep is simple, allowing users to maintain cleanliness without hassle. Overall, the SafeRest Waterproof Queen Size Mattress Protector combines practical design with user-friendly features to deliver lasting mattress protection and peace of mind.

To buy this product, click here.

Utopia Bedding Waterproof Mattress Protector Queen Size

The Utopia Bedding Waterproof Mattress Protector Queen Size is ideal for individuals seeking to safeguard their mattresses from spills, allergens, and bed bugs. It is especially suitable for allergy sufferers, families with children, pet owners, and anyone wanting to extend the life of their mattress while maintaining hygiene and comfort.

Pros:

• Waterproof and absorbent material protects against spills and stains
• Six-sided zippered encasement offers full mattress protection, including bed bug and dust mite proofing
• Fits mattresses up to 15 inches in height, suitable for most queen-size beds
• Made by trusted Utopia Bedding brand ensuring quality and durability
• White color blends easily with any bedding decor

Cons:

• May produce slight crinkling noise due to waterproof layer
• Zipper encasement can be slightly tricky to install for some users

The Utopia Bedding Waterproof Mattress Protector boasts a comprehensive six-sided zippered design that completely encases your queen-size mattress, effectively blocking out bed bugs, dust mites, and allergens. This feature not only ensures a hygienic sleeping environment but also provides peace of mind for those sensitive to airborne irritants. The waterproof and absorbent fabric protects your mattress from accidental spills and stains, helping to maintain its cleanliness and extend its lifespan.

Designed to fit mattresses up to 15 inches deep, this encasement covers the top, sides, and bottom of your mattress, offering all-around protection. The zipper closure is secure and durable, preventing unwanted pests from entering while allowing easy removal for washing. Additionally, the breathable yet protective material helps maintain comfort by regulating temperature and reducing moisture buildup, making it an excellent choice for restful and uninterrupted sleep.

To buy this product, click here.

Frequently Asked Questions

What Makes A Mattress Cover Allergy-proof?

An allergy-proof mattress cover blocks dust mites, bed bugs, and allergens. It uses hypoallergenic, breathable materials for comfort and protection. Waterproof and zippered designs enhance defense against allergens and spills, ensuring a healthier sleep environment.

How Does A Zippered Mattress Encasement Help Allergies?

A zippered mattress encasement fully seals the mattress, preventing dust mites and allergens from entering. It creates a barrier that stops bed bugs and allergens from escaping. This helps reduce allergy symptoms and improves overall sleep quality.

Are Waterproof Mattress Protectors Effective For Allergies?

Yes, waterproof mattress protectors prevent liquids and allergens from penetrating the mattress. They keep the mattress dry and free from dust mites and mold. This protection reduces allergen exposure and helps maintain a clean sleeping surface.

Can Mattress Covers Reduce Asthma Symptoms?

Mattress covers reduce asthma triggers by blocking dust mites and allergens. They create a hypoallergenic barrier that minimizes exposure to irritants. Using a quality allergy mattress cover can help improve breathing and sleep quality for asthma sufferers.

How Often Should Allergy Mattress Covers Be Washed?

Allergy mattress covers should be washed every 1-2 months. Regular washing removes dust mites, allergens, and bacteria. Follow manufacturer instructions for best results and to maintain the cover’s protective qualities and durability.

Conclusion

Choosing the best allergy cover for your mattress helps create a healthier sleep space. These mattress protectors stop dust mites, bed bugs, and allergens from reaching you. They also keep your mattress clean and dry with waterproof features. Many options, like zippered encasements and stretchable fitted covers, fit different mattress sizes easily.

Materials like cotton and hypoallergenic fabrics add comfort and breathability. Machine washable designs make cleaning simple and stress-free. Picking a quality allergy mattress cover can reduce allergy symptoms and improve sleep quality. It’s a small change that makes a big difference for sensitive sleepers.

Remember to check depth, material, and protection level before buying. A well-chosen mattress cover protects your health and extends mattress life. Sleep better, breathe easier, and enjoy nights free from allergy worries with the right mattress cover.